Résumé: For the first time, enantiopure 1-r-oxo-2-c,5-t-diphenylphospholane was introduced as nucleophile in the multicomponent condensation reaction. Diastereoisomers of 2,5-diphenyl-1-oxo- 1-[alkylphenyl-1-(phenylamino) methyl] phospholane derivatives were synthesized by one-pot process from aromatic aldehydes, anilines and enantiopure1-r-oxo-2-c,5-t-diphenylphospholane under green and eco-compatible conditions. The reaction proceeds under catalyst-free conditions at room temperature within very short time (3 min) in excellent yields (up to 95%). An X-ray crystal structure has been obtained for 2,5-diphenyl-1-oxo-1-[phenyl (phenylamino) methyl] phospholane.

Résumé: New bis(a-aminophosphonates) were directly prepared with high diastereoselectivity by lipase catalytic promiscuity in the presence of immobilized Candida antarctica lipase. We focused on the multi-component Kabachnik–Fields reaction using various aldehydes, benzidine, and diethylphosphite in one pot. The reaction proceeded with short reaction times with good to excellent yields. The CAL-B was easily recovered and reused several times. A total diastereoselectivity was observed for bis(a-aminophosphonates) 4a, 4c, 4h, 4i, 4k and was high for 4b, 4f and 4j.