Résumé: ABSTRACT The aim of this research is to examine the potential protective effect of Sesamum indicum L (SS) against reproductive toxicity induced by Ethylene Glycol Monomethyl Ether (EGME) in male rabbits (Oryctolagus cuniculus). Twenty-four adult rabbits were split equally into four groups (n=6): control, SS (150 mg/kg bw), EGME (150 mg/kg bw), and combined group (EGME-SS). The rabbits were orally administered the respective treatments daily for a period of four weeks. The effects on sperm biology, serum testosterone levels, and oxidative stress markers in the testicular tissue were evaluated, along with the histology of the testis and epididymis. The findings showed that EGME had a deleterious effect, as seen by a marked drop in blood testosterone levels and spermatozoa motility, concentration, and speed. Nonetheless, the testosterone concentration and sperm biology of the SS group were significantly improved. Interestingly, the EGME-SS group exhibited markers that were nearly the same as the control group, except for significantly higher spermatozoa concentration, highlighting the beneficial use of sesame. The EGME treatment led to an increase in lipid peroxidation levels, while concentrations of GSH, GPX, and CAT in the testes decreased in contrast to the control group. However, the concurrent supplementation of sesame significantly alleviated testicular GSH, GPX, and CAT concentration. Histological analysis revealed changes and damage in the testes and epididymis tissues of EGME-treated rabbits, including the absence of spermatozoa in several seminiferous tubules. In contrast, the histology of organs in the EGME-SS group showed less deterioration, indicating the preventive activity of sesame against EGME-induced toxicity. Keywords : Ethylene glycol monomethyl ether, Reproductive toxicity, Sesamum indicum L, Reproductive protection, Male rabbit

Résumé: Abstract Treatment with medical leeches has been available since ancient times and has been used for more than 2,500 years by Egyptians, Indians, Greeks and Arabs as a treatment for some specific diseases such as skin diseases, infections, etc. Medical leeches provide medical benefits by absorbing blood and delivering many biologically active substances Recently, this technology has reached the widest field of application, so we focused on medical leeches from a morphological standpoint, as they are blood-sucking worms that live in fresh water. Their bodies are divided into rings and they have two suckers, anterior at the front of the body and posterior at the end. . On the other hand, we discussed the role of medical leeches To handle a case of some diseases, for example, osteoporosis, due to the various active substances contained in its saliva. The results showed a significant improvement in the patient’s health condition. Keywords: osteoporosis, medical leeches, Patients.

Résumé: Numerous studies have demonstrated that pesticides are toxic and harmful to human, animal, and environmental health. Glyphosate is the most widely used herbicide globally. This research aimed to assess the impacts of various dosages of glyphosate on rabbits. A total of 30 rabbits were divided into four groups: one control group and three treatment groups, with three concentrations of glyphosate selected as D1 (200 mg/kg/bw). The treatment groups were administered glyphosate at a dosage of 1 mL/day for 6 days per week over 4 weeks. The findings substantially reduced several hematological parameters, including hemoglobin, erythrocytes, leukocytes, hematocrit, and platelets. At the same time, the levels of white blood cells and lymphocytes increased significantly in all glyphosate-treated groups compared to the control group. Additionally, changes were observed in the liver, thymus, and kidney tissues, including alterations in hepatocyte cells, portal blood vessel congestion, inflammatory cell infiltration, and necrosis of sporadic hepatocytes.

Résumé: Treatment with medical leeches has been available since ancient times and has been used for more than 2,500 years by Egyptians, Indians, Greeks and Arabs as a treatment for some specific diseases such as skin diseases, infections, etc. Medical leeches provide medical benefits by absorbing blood and delivering many biologically active substances Recently, this technology has reached the widest field of application, so we focused on medical leeches from a morphological standpoint, as they are blood-sucking worms that live in fresh water. Their bodies are divided into rings and they have two suckers, anterior at the front of the body and posterior at the end. . On the other hand, we discussed the role of medical leeches To handle a case of some diseases, for example, osteoporosis, due to the various active substances contained in its saliva. The results showed a significant improvement in the patient’s health conditio

Résumé: This work examines the effect of three doses of zinc oxide nanoparticles (ZnONPs), synthetized with Crataegus monogyna leaves using zinc acetate, on the sperm quality of Wistar rats. Animals were divided into 4 groups; the control group maintained without treatment, while ZNP1, ZNP2, and ZNP3 received respectively 10 mg ZNP/kgbw, 50 mg ZNP/kgbw, and 100 mg ZNP/kgbw by gavage for 15 days. Epididymis sperm was collected for sperm parameters: concentration, live sperm, motility, velocity (VCL, VSL, and VAP), linearity (LIN), amplitude lateral head (ALH), and beat cross frequency (BCF). DNA fragmentation was measured in three samples selected from control, ZNP1, and ZNP2. Testicular and epididymis malondialdehyde (MDA), glutathione (GSH), and glutathione peroxidase (GPx) were evaluated. Compared to the control, ZNP1 has a significant reduction of testicular and epididymis weights, sperm concentration, live sperm, motility, VCL, VSL, VAP, LIN, and BCF, with a significant increase of MDA and a significant decrease of GSH levels. The ZNP2 group demonstrated a significant increase in epididymis weight, a raise in sperm parameters (concentration, motility, VCL VSL, VAP, LIN, ALH, and BCF), and an augmentation in GSH and GPx levels. However, ZNP3 has a significant increase in VSL and ALH while ZNP1 and ZNP2 showed no effect on spermatozoa DNA. interestedly, we found that the lower dose of ZNP1 acted as toxic to testicular and epididymis parameters, while the higher ones may help to improve sperm quality and reduced oxidative stress. Keywords: zinc oxide; nanoparticles; Crataegus monogyna ; sperm quality.

Résumé: This work examines the effect of three doses of zinc oxide nanoparticles (ZnONPs), synthetized with Crataegus monogyna leaves using zinc acetate, on the sperm quality of Wistar rats. Animals were divided into 4 groups; the control group maintained without treatment, while ZNP1, ZNP2, and ZNP3 received respectively 10 mg ZNP/kgbw, 50 mg ZNP/kgbw, and 100 mg ZNP/kgbw by gavage for 15 days. Epididymis sperm was collected for sperm parameters: concentration, live sperm, motility, velocity (VCL, VSL, and VAP), linearity (LIN), amplitude lateral head (ALH), and beat cross frequency (BCF). DNA fragmentation was measured in three samples selected from control, ZNP1, and ZNP2. Testicular and epididymis malondialdehyde (MDA), glutathione (GSH), and glutathione peroxidase (GPx) were evaluated. Compared to the control, ZNP1 has a significant reduction of testicular and epididymis weights, sperm concentration, live sperm, motility, VCL, VSL, VAP, LIN, and BCF, with a significant increase of MDA and a significant decrease of GSH levels. The ZNP2 group demonstrated a significant increase in epididymis weight, a raise in sperm parameters (concentration, motility, VCL VSL, VAP, LIN, ALH, and BCF), and an augmentation in GSH and GPx levels. However, ZNP3 has a significant increase in VSL and ALH while ZNP1 and ZNP2 showed no effect on spermatozoa DNA. interestedly, we found that the lower dose of ZNP1 acted as toxic to testicular and epididymis parameters, while the higher ones may help to improve sperm quality and reduced oxidative stress. Keywords: zinc oxide; nanoparticles; Crataegus monogyna ; sperm quality.