Résumé: Diabetes mellitus is a non-communicable disease affecting 463 million people across the world. Ginger has enormous health promoting potential effects in number of ailments including diabetes. So, the purpose of this study was to evaluate the beneficial effect of ginger (Zingiber officinale Roscoe) supplementation on carbohydrate metabolism, antioxidant status and tissue zinc in diabetic rats fed zinc deficient diet. Rats were divided into four groups. The first group was non-diabetic rats fed adequate zinc diet. The second was diabetic group fed also adequate zinc diet. While, the third and the fourth groups were diabetic fed zinc deficient diet, one non-treated and the other treated with ginger 2% diet. The findings showed an increase of blood glucose, transaminases, lipids profile and malondialdehyde levels, whereasinsulin, liverzinc, alkaline phosphatase, lactate dehydrogenase, proteins, reduced glutathione and antioxidant enzymes were reduced in zinc deficient rats. However, treatment with ginger restored the previous parameters. The obtained results indicated that ginger has a powerful effect, which led to a reduction of diabetes development in zinc deficiency due to its antioxidant potential.

Résumé: Zinc is recognized to have a crucial function in insulin production. As a result, its absence may have a deleterious impact on the progression of diabetes and associated consequences. So, this study was undertaken to evaluate the effect of sesame oil on biochemical parameters, zinc status, and oxidative stress biomarkers in streptozotocin (STZ)-induced diabetic rats fed zinc-deficient diet. Rats were divided into four groups. The first group consisted of non-diabetic rats that were fed in a sufficient zinc diet, whereas the second was a diabetic group which received also sufficient zinc diet, while the third and fourth groups were diabetic rats fed in a deficient zinc diet, one was non-treated and the other was treated with sesame oil 6% diet for 27 days. Zinc deficiency has affected the weight of the diabetic animals. It was also noticed that inadequate dietary zinc intake increased concentrations of glucose, cholesterol, triglycerides, malondialdehyde, and transaminases activities. Furthermore, zinc deficiency feed provoked a decrease in zinc level in tissues (femur, liver, and pancreas); glutathione concentration; and lactic dehydrogenase, amylase, catalase, superoxide dismutase, and glutathione-S-transferase activities. However, sesame oil treatment ameliorated all the previous parameters approximately to their normal values. It was found out that sesame oil supplementation is a potent factor in mitigating the oxidative severity of zinc deficiency in diabetes through its effective antioxidant potential.

Résumé: The purpose of this study was to evaluate the beneficial effect of vitamin C supplementation on biochemical parameters, antioxidant status, and zinc status in diabetic rats fed zinc-deficient diet. Forty male albino Wistar rats were divided into 5 groups. The first group was non-diabetic rats. The second and third groups were diabetic given a zinc-adequate diet (ZA); and zinc-deficient diet (ZD) respectively. The forth and the fifth groups received also a zinc adequate diet and zinc-deficient diet with supplementation of vitamin (ZA+VitC and ZD+VitC). Diabetes was induced with alloxan. Body weight and food intake were measured regularly. After four weeks of dietary manipulation, the fasting animals were killed. The results revealed that dietary zinc intake significantly increased glucose, lipids, triglycerides, urea, AST, ALT, liver GST and TBARS levels in ZD rats. In contrast, the levels of zinc, total proteins, ALP, LDH, liver glycogen, GSH, GSH-Px and CAT were decreased. Interestingly, vitamin C seems to be effective in restoring the previous parameters to their normal levels. It can be assumed that vitamin C supplementation acted as an antioxidant, which significantly reduced the severity of zinc-deficiency metabolic perturbations in diabetic rats.

Résumé: Background: The bioavailability of zinc can be influenced by several dietary factors, among them calcium level, which leads to zinc metabolism disturbance. Thus, the present study was under taken to evaluate the effect of zinc supplementation on zinc status and carbohydrate metabolism in non-diabetic and diabetic rats fed high-calcium diet. Methods: Sixty male Wistar rats were randomly divided into six equal groups. The first and fourth groups were non-diabetic and diabetic controls respectively. The second, third, fifth and sixth groups were calcium, calcium + zinc, diabetes + calcium and diabetes + calcium + zinc groups, respectively. Diabetes in fourth, fifth and sixth groups were induced by alloxan. Calcium (35 mg/kg feed) as CaCO3 and zinc (231 mg/kg feed) as ZnSO4.7H2 O in feed were supplemented to the animals in groups for 21 days. Results: High dietary calcium significantly decreased body weight gain, serum zinc, tissue zinc levels, alkaline phosphatase, lactic dehydrogenases and aldolase activities and led to an increase of cholesterol, transaminases and uric acid concentrations in both diabetic and non-diabetic rats. However, zinc supplementation in animals fed calcium assured a partial correction of the previous parameters. Conclusion: The investigation revealed that zinc supplementation has a positive role against the negative effect of calcium, which provoked metabolic disturbance in diabetic and non-diabetic rats